[B-cell and cytotoxic lymphocyte immune response to virulent, attenuated and reassortant influenza viruses].
Identifieur interne : 002E40 ( Main/Exploration ); précédent : 002E39; suivant : 002E41[B-cell and cytotoxic lymphocyte immune response to virulent, attenuated and reassortant influenza viruses].
Auteurs : A R Rekstin ; A N Na Khin ; I B Barantseva ; L G RudenkoSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (analyse), Basse température, Glycoprotéine hémagglutinine du virus influenza (génétique), Immunisation, Immunoglobuline A (analyse), Immunoglobuline G (analyse), Immunoglobuline M (analyse), Lymphocytes B (immunologie), Lymphocytes T cytotoxiques (immunologie), Mémoire immunologique, Noeuds lymphatiques (immunologie), Rate (immunologie), Sialidase (génétique), Souris, Souris de lignée BALB C, Spécificité d'espèce, Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus recombinants (immunologie).
- MESH :
- analyse : Anticorps antiviraux, Immunoglobuline A, Immunoglobuline G, Immunoglobuline M.
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sialidase, Virus de la grippe A.
- immunologie : Lymphocytes B, Lymphocytes T cytotoxiques, Noeuds lymphatiques, Rate, Virus de la grippe A, Virus recombinants.
- Animaux, Basse température, Immunisation, Mémoire immunologique, Souris, Souris de lignée BALB C, Spécificité d'espèce.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (analysis), B-Lymphocytes (immunology), Cold Temperature, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Immunization, Immunoglobulin A (analysis), Immunoglobulin G (analysis), Immunoglobulin M (analysis), Immunologic Memory, Influenza A virus (genetics), Influenza A virus (immunology), Lymph Nodes (immunology), Mice, Mice, Inbred BALB C, Neuraminidase (genetics), Reassortant Viruses (immunology), Species Specificity, Spleen (immunology), T-Lymphocytes, Cytotoxic (immunology).
- MESH :
- chemical , analysis : Antibodies, Viral, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Neuraminidase.
- genetics : Influenza A virus.
- immunology : B-Lymphocytes, Influenza A virus, Lymph Nodes, Reassortant Viruses, Spleen, T-Lymphocytes, Cytotoxic.
- Animals, Cold Temperature, Immunization, Immunologic Memory, Mice, Mice, Inbred BALB C, Species Specificity.
Abstract
The quantitative estimation of the production of the virus specific IgA-, IgM-, IgG1, IgG2a, IgG2b and IgG3-antibody secreting B-cells (ASC) and extent of the immune response of the cytotoxic T-lymphocytes was carried out in mice after primary and secondary immunization with the parental cold adapted (ca) virulent epidemic wild-type (wt) master strain viruses and their reassortant variant (RV) with the incorporated in their genom different genes from ca master strain. The chick embryo derived ca master strain virus A/Len/134/47/57 (H2N2) reduced or eliminated the viral potency to induce the primary B-cellular response. Reassortant incorporation of wt derived HA and NA genes into the ca virus genome restored the virus immunogenic activity concerning the ASC production, but at the lower level than parental virulent virus. Reassortance of the viruses according to generally accepted genom formula 6/2 was associated with decrement of the functional activity of the cytotoxic T-lymphocytes memory and of the primary immune response especially. The data obtain demonstrate the necessity for the control of the immunogenicity of the reassortant viruses at the cloning stage.
PubMed: 12271722
Affiliations:
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Le document en format XML
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viruses].</title><author><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A R" last="Rekstin">A R Rekstin</name></author><author><name sortKey="Na Khin, A N" sort="Na Khin, A N" uniqKey="Na Khin A" first="A N" last="Na Khin">A N Na Khin</name></author><author><name sortKey="Barantseva, I B" sort="Barantseva, I B" uniqKey="Barantseva I" first="I B" last="Barantseva">I B Barantseva</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (analysis)</term><term>B-Lymphocytes (immunology)</term><term>Cold Temperature</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Immunization</term><term>Immunoglobulin A (analysis)</term><term>Immunoglobulin G (analysis)</term><term>Immunoglobulin M (analysis)</term><term>Immunologic Memory</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Lymph Nodes (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Neuraminidase (genetics)</term><term>Reassortant Viruses (immunology)</term><term>Species Specificity</term><term>Spleen (immunology)</term><term>T-Lymphocytes, Cytotoxic (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (analyse)</term><term>Basse température</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Immunisation</term><term>Immunoglobuline A (analyse)</term><term>Immunoglobuline G (analyse)</term><term>Immunoglobuline M (analyse)</term><term>Lymphocytes B (immunologie)</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Mémoire immunologique</term><term>Noeuds lymphatiques (immunologie)</term><term>Rate (immunologie)</term><term>Sialidase (génétique)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Spécificité d'espèce</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term><term>Virus recombinants (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin A</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Neuraminidase</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline A</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sialidase</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes B</term><term>Lymphocytes T cytotoxiques</term><term>Noeuds lymphatiques</term><term>Rate</term><term>Virus de la grippe A</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term><term>Influenza A virus</term><term>Lymph Nodes</term><term>Reassortant Viruses</term><term>Spleen</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cold Temperature</term><term>Immunization</term><term>Immunologic Memory</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Species Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Basse température</term><term>Immunisation</term><term>Mémoire immunologique</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Spécificité d'espèce</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The quantitative estimation of the production of the virus specific IgA-, IgM-, IgG1, IgG2a, IgG2b and IgG3-antibody secreting B-cells (ASC) and extent of the immune response of the cytotoxic T-lymphocytes was carried out in mice after primary and secondary immunization with the parental cold adapted (ca) virulent epidemic wild-type (wt) master strain viruses and their reassortant variant (RV) with the incorporated in their genom different genes from ca master strain. The chick embryo derived ca master strain virus A/Len/134/47/57 (H2N2) reduced or eliminated the viral potency to induce the primary B-cellular response. Reassortant incorporation of wt derived HA and NA genes into the ca virus genome restored the virus immunogenic activity concerning the ASC production, but at the lower level than parental virulent virus. Reassortance of the viruses according to generally accepted genom formula 6/2 was associated with decrement of the functional activity of the cytotoxic T-lymphocytes memory and of the primary immune response especially. The data obtain demonstrate the necessity for the control of the immunogenicity of the reassortant viruses at the cloning stage.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Barantseva, I B" sort="Barantseva, I B" uniqKey="Barantseva I" first="I B" last="Barantseva">I B Barantseva</name><name sortKey="Na Khin, A N" sort="Na Khin, A N" uniqKey="Na Khin A" first="A N" last="Na Khin">A N Na Khin</name><name sortKey="Rekstin, A R" sort="Rekstin, A R" uniqKey="Rekstin A" first="A R" last="Rekstin">A R Rekstin</name><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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